Ontology highlight
ABSTRACT:
SUBMITTER: Di Dedda C
PROVIDER: S-EPMC6801424 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Di Dedda Carla C Vignali Debora D Piemonti Lorenzo L Monti Paolo P
International journal of molecular sciences 20191008 19
An increasing body of evidence indicates that bio-energetic metabolism of T cells can be manipulated to control T cell responses. This potentially finds a field of application in the control of the T cell responses in autoimmune diseases, including in type 1 diabetes (T1D). Of the possible metabolic targets, Glut1 gained considerable interest because of its pivotal role in glucose uptake to fuel glycolysis in activated T cells, and the recent development of a novel class of small molecules that ...[more]