Ontology highlight
ABSTRACT:
SUBMITTER: Sun CY
PROVIDER: S-EPMC6801623 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Sun Cheng-Yuan CY Zhang Xiao-Peng XP Wang Wei W
International journal of molecular sciences 20190926 19
p53-targeted microRNAs (miRNAs) markedly affect cellular response to DNA damage. These miRNAs may contribute to either cell cycle arrest or apoptosis induction. However, how these miRNAs coordinate to modulate the decision between cell survival and death remains less understood. Here, we developed an integrated model of p53 signaling network to investigate how p53-targeted <i>miR-192</i> and <i>miR-22</i> modulate cellular outcome in response to DNA damage. By numerical simulations, we found tha ...[more]