Ontology highlight
ABSTRACT:
SUBMITTER: Hwang JW
PROVIDER: S-EPMC6801716 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Hwang Jin Wook JW Desterke Christophe C Féraud Olivier O Richard Stephane S Ferlicot Sophie S Verkarre Virginie V Patard Jean Jacques JJ Loisel-Duwattez Julien J Foudi Adlen A Griscelli Frank F Bennaceur-Griscelli Annelise A Turhan Ali G AG
International journal of molecular sciences 20190930 19
Hereditary cancers with cancer-predisposing mutations represent unique models of human oncogenesis, as a driving oncogenic event is present in germline. Currently, there are no satisfactory models to study these malignancies. We report the generation of IPSC from the somatic cells of a patient with hereditary c-<i>met-</i>mutated papillary renal cell carcinoma (PRCC). From these cells we have generated spontaneous aggregates organizing in structures which expressed kidney markers such as PODXL a ...[more]