Ontology highlight
ABSTRACT:
SUBMITTER: Albuquerque-Wendt A
PROVIDER: S-EPMC6801728 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Albuquerque-Wendt Andreia A Hütte Hermann J HJ Buettner Falk F R FFR Routier Françoise H FH Bakker Hans H
International journal of molecular sciences 20190929 19
Glycosyltransferases that use polyisoprenol-linked donor substrates are categorized in the GT-C superfamily. In eukaryotes, they act in the endoplasmic reticulum (ER) lumen and are involved in <i>N</i>-glycosylation, glypiation, <i>O</i>-mannosylation, and <i>C</i>-mannosylation of proteins. We generated a membrane topology model of <i>C</i>-mannosyltransferases (DPY19 family) that concurred perfectly with the 13 transmembrane domains (TMDs) observed in oligosaccharyltransferases (STT3 family) s ...[more]