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MicroRNAs in Cardiac Hypertrophy.

ABSTRACT: Like other organs, the heart undergoes normal adaptive remodeling, such as cardiac hypertrophy, with age. This remodeling, however, is intensified under stress and pathological conditions. Cardiac remodeling could be beneficial for a short period of time, to maintain a normal cardiac output in times of need; however, chronic cardiac hypertrophy may lead to heart failure and death. MicroRNAs (miRNAs) are known to have a role in the regulation of cardiac hypertrophy. This paper reviews recent advances in the field of miRNAs and cardiac hypertrophy, highlighting the latest findings for targeted genes and involved signaling pathways. By targeting pro-hypertrophic genes and signaling pathways, some of these miRNAs alleviate cardiac hypertrophy, while others enhance it. Therefore, miRNAs represent very promising potential pharmacotherapeutic targets for the management and treatment of cardiac hypertrophy.

SUBMITTER: Wehbe N

PROVIDER: S-EPMC6801828 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature

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MicroRNAs in Cardiac Hypertrophy.

Wehbe Nadine N Nasser Suzanne Awani SA Pintus Gianfranco G Badran Adnan A Eid Ali H AH Baydoun Elias E

International journal of molecular sciences 20190923 19

Like other organs, the heart undergoes normal adaptive remodeling, such as cardiac hypertrophy, with age. This remodeling, however, is intensified under stress and pathological conditions. Cardiac remodeling could be beneficial for a short period of time, to maintain a normal cardiac output in times of need; however, chronic cardiac hypertrophy may lead to heart failure and death. MicroRNAs (miRNAs) are known to have a role in the regulation of cardiac hypertrophy. This paper reviews recent adva ...[more]

PMID: 31547607

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