Effects of closed-loop automatic control of the inspiratory fraction of oxygen (FiO2-C) on outcome of extremely preterm infants - study protocol of a randomized controlled parallel group multicenter trial for safety and efficacy.
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ABSTRACT:
SUBMITTER: Maiwald CA
PROVIDER: S-EPMC6802113 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
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Effects of closed-loop automatic control of the inspiratory fraction of oxygen (FiO<sub>2</sub>-C) on outcome of extremely preterm infants - study protocol of a randomized controlled parallel group multicenter trial for safety and efficacy.
Maiwald Christian A CA Niemarkt Hendrik J HJ Poets Christian F CF Urschitz Michael S MS König Jochem J Hummler Helmut H Bassler Dirk D Engel Corinna C Franz Axel R AR
BMC pediatrics 20191021 1
<h4>Background</h4>Most extremely low gestational age neonates (ELGANS, postmenstrual age at birth (PMA) < 28 completed weeks) require supplemental oxygen and experience frequent intermittent hypoxemic and hyperoxemic episodes. Hypoxemic episodes and exposure to inadequately high concentrations of oxygen are associated with an increased risk of retinopathy of prematurity (ROP), chronic lung disease of prematurity (BPD), necrotizing enterocolitis (NEC), neurodevelopmental impairment (NDI), and de ...[more]
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