Ontology highlight
ABSTRACT:
SUBMITTER: Park J
PROVIDER: S-EPMC6802832 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
PloS one 20191021 10
The circadian clock and aging are intertwined. Disruption to the normal diurnal rhythm accelerates aging and corresponds with telomere shortening. Telomere attrition also correlates with increase cellular senescence and incidence of chronic disease. In this report, we examined diurnal association of White Collar 2 (WC-2) in Neurospora and BMAL1 in zebrafish and mice and found that these circadian transcription factors associate with telomere DNA in a rhythmic fashion. We also identified a circad ...[more]