Focus on the glycerophosphocholine pathway in choline phospholipid metabolism of cancer.
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ABSTRACT:
SUBMITTER: Sonkar K
PROVIDER: S-EPMC6803034 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
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Focus on the glycerophosphocholine pathway in choline phospholipid metabolism of cancer.
Sonkar Kanchan K Ayyappan Vinay V Tressler Caitlin M CM Adelaja Oluwatobi O Cai Ruoqing R Cheng Menglin M Glunde Kristine K
NMR in biomedicine 20190611 10
Activated choline metabolism is a hallmark of carcinogenesis and tumor progression, which leads to elevated levels of phosphocholine and glycerophosphocholine in all types of cancer tested so far. Magnetic resonance spectroscopy applications have played a key role in detecting these elevated choline phospholipid metabolites. To date, the majority of cancer-related studies have focused on phosphocholine and the Kennedy pathway, which constitutes the biosynthesis pathway for membrane phosphatidylc ...[more]
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