Unknown

Dataset Information

0

MYC gene associated polymorphisms and Wilms tumor risk in Chinese children: a four-center case-control study.


ABSTRACT:

Background

Wilms tumor (WT) is a common embryonal malignancy in the kidney, ranking fourth in childhood cancer worldwide. MYC, a critical proto-oncogene, plays an important role in tumorigenesis. Single nucleotide polymorphisms in the MYC gene may lead to the deregulation of MYC proto-oncogene protein and thereby promote the initiation and development of tumors.

Methods

Here, we assessed the association between MYC gene associated polymorphisms and WT susceptibility by performing a case-control study with 355 cases and 1070 controls. Two MYC gene associated polymorphisms (rs4645943 C > T, rs2070583 A > G) were genotyped by TaqMan technique. Odds ratios (ORs) and 95% confidence intervals (CIs) were used for evaluating the association between these two polymorphisms and WT susceptibility.

Results

No significant association was detected between the selected polymorphisms and WT risk in the overall analysis as well as stratification analysis.

Conclusions

These results indicate that neither of two selected MYC gene associated polymorphisms might affect WT susceptibility in the Chinese population. Large well-designed studies with diverse ethnicities are warranted to verify these results.

SUBMITTER: Liu J 

PROVIDER: S-EPMC6803173 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature

altmetric image

Publications

<i>MYC</i> gene associated polymorphisms and Wilms tumor risk in Chinese children: a four-center case-control study.

Liu Jiabin J   Hua Rui-Xi RX   Fu Wen W   Zhu Jinhong J   Jia Wei W   Zhang Jiao J   Zhou Haixia H   Cheng Jiwen J   Xia Huimin H   Liu Guochang G   He Jing J  

Annals of translational medicine 20190901 18


<h4>Background</h4>Wilms tumor (WT) is a common embryonal malignancy in the kidney, ranking fourth in childhood cancer worldwide. <i>MYC</i>, a critical proto-oncogene, plays an important role in tumorigenesis. Single nucleotide polymorphisms in the <i>MYC</i> gene may lead to the deregulation of <i>MYC</i> proto-oncogene protein and thereby promote the initiation and development of tumors.<h4>Methods</h4>Here, we assessed the association between <i>MYC</i> gene associated polymorphisms and WT s  ...[more]

Similar Datasets

| S-EPMC8077085 | biostudies-literature
| S-EPMC10344549 | biostudies-literature
| S-EPMC7307367 | biostudies-literature
| S-EPMC6340947 | biostudies-literature
| S-EPMC10240673 | biostudies-literature
| S-EPMC6428095 | biostudies-literature
| S-EPMC8373325 | biostudies-literature
| S-EPMC6128416 | biostudies-literature
| S-EPMC7938399 | biostudies-literature