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MYC gene associated polymorphisms and Wilms tumor risk in Chinese children: a four-center case-control study.

ABSTRACT: Background:Wilms tumor (WT) is a common embryonal malignancy in the kidney, ranking fourth in childhood cancer worldwide. MYC, a critical proto-oncogene, plays an important role in tumorigenesis. Single nucleotide polymorphisms in the MYC gene may lead to the deregulation of MYC proto-oncogene protein and thereby promote the initiation and development of tumors. Methods:Here, we assessed the association between MYC gene associated polymorphisms and WT susceptibility by performing a case-control study with 355 cases and 1070 controls. Two MYC gene associated polymorphisms (rs4645943 C > T, rs2070583 A > G) were genotyped by TaqMan technique. Odds ratios (ORs) and 95% confidence intervals (CIs) were used for evaluating the association between these two polymorphisms and WT susceptibility. Results:No significant association was detected between the selected polymorphisms and WT risk in the overall analysis as well as stratification analysis. Conclusions:These results indicate that neither of two selected MYC gene associated polymorphisms might affect WT susceptibility in the Chinese population. Large well-designed studies with diverse ethnicities are warranted to verify these results.

SUBMITTER: Liu J

PROVIDER: S-EPMC6803173 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature

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<i>MYC</i> gene associated polymorphisms and Wilms tumor risk in Chinese children: a four-center case-control study.

Liu Jiabin J Hua Rui-Xi RX Fu Wen W Zhu Jinhong J Jia Wei W Zhang Jiao J Zhou Haixia H Cheng Jiwen J Xia Huimin H Liu Guochang G He Jing J

Annals of translational medicine 20190901 18

<h4>Background</h4>Wilms tumor (WT) is a common embryonal malignancy in the kidney, ranking fourth in childhood cancer worldwide. <i>MYC</i>, a critical proto-oncogene, plays an important role in tumorigenesis. Single nucleotide polymorphisms in the <i>MYC</i> gene may lead to the deregulation of <i>MYC</i> proto-oncogene protein and thereby promote the initiation and development of tumors.<h4>Methods</h4>Here, we assessed the association between <i>MYC</i> gene associated polymorphisms and WT s ...[more]

PMID: 31700911

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Project description:BackgroundWilms tumor is the most common pediatric renal cancer. However, genetic bases behind Wilms tumor remain largely unknown. H19 is a critical maternally imprinted gene. Previous studies indicated that single nucleotide polymorphisms (SNPs) in the H19 can modify the risk of several human malignancies. Epigenetic errors at the H19 locus lead to biallelic silencing in Wilms tumors. Genetic variations in the H19 may be related to Wilms tumor susceptibility.MethodsWe conducted a four-center study to investigate whether H19 SNP was a predisposing factor to Wilms tumor. Three polymorphisms in the H19 (rs2839698 G > A, rs3024270 C > G, rs217727 G > A) were genotyped in 355 cases and 1070 cancer-free controls, using Taqman method. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to evaluate the strength of the associations.ResultsWe found that all of these three polymorphisms were significantly associated with Wilms tumor risk alterations. The rs2839698 G > A polymorphism (AG vs. GG: adjusted OR = 0.74, 95% CI = 0.57-0.96, p = 0.024; AA vs. GG: adjusted OR = 1.52, 95% CI = 1.05-2.22, p = 0.027), the rs3024270 C > G polymorphism (CG vs. CC: adjusted OR = 0.61, 95% CI = 0.46-0.81, p = 0.0007; and the rs217727 polymorphism (AG vs. GG: adjusted OR = 0.76, 95% CI = 0.58-0.99, p = 0.035). The Carriers of 1, 2, and 1-2 risk genotypes were inclined to develop Wilms tumor compared with those without risk genotype (adjusted OR = 1.36, 95% CI = 1.02-1.80, p = 0.037; adjusted OR = 1.84, 95% CI = 1.27-2.67, p = 0.001; adjusted OR = 1.50, 95% CI = 1.17-1.92, p = 0.002, respectively). The stratified analysis further revealed that rs2839698 AA, rs217727 AA, and 1-2 risk genotypes could strongly increase Wilms tumor risk among children above 18 months of age, males, and with clinical stage I+II disease.ConclusionOur findings indicate that genetic variations in the H19 may confer Wilms tumor risk.

Dataset Information

MYC gene associated polymorphisms and Wilms tumor risk in Chinese children: a four-center case-control study.

Publications

<i>MYC</i> gene associated polymorphisms and Wilms tumor risk in Chinese children: a four-center case-control study.

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