Ontology highlight
ABSTRACT:
SUBMITTER: Rondon RE
PROVIDER: S-EPMC6803630 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Rondon Ronald E RE Groseclose Thomas M TM Short Andrew E AE Wilson Corey J CJ
Nature communications 20191021 1
The control of gene expression is an important tool for metabolic engineering, the design of synthetic gene networks, and protein manufacturing. The most successful approaches to date are based on modulating mRNA synthesis via an inducible coupling to transcriptional effectors. Here we present a biological programming structure that leverages a system of engineered transcription factors and complementary genetic architectures. We use a modular design strategy to create 27 non-natural and non-syn ...[more]