Dataset Information

PDE4B gene polymorphism in Russian patients with panic disorder.

ABSTRACT: Background:Panic disorder is a complex disease of unclear etiology but with an apparent genetic component. PDE4B gene product is involved in many cell processes owing to its function-regulation of the level of a second messenger cAMP. PDE4B gene polymorphism has been shown to be associated with some mental disorders including panic disorder. Aims:The goal of our study was to evaluate the role of 3 SNPs in the PDE4B gene in the development of panic disorder. Methods:94 patients diagnosed with panic disorder according to the DSM-IV criteria were enrolled in the study. The population control group included 192 subjects. Genotyping was carried out by real-time PCR with TaqMan probes. Results:The investigated substitutions are not associated with panic disorder in general and in female/male cohorts (p > 0.05). The analysis of complex genotypes demonstrated two protective complex genotypes (rs1040716:A, T + rs10454453:A + rs502958:A and rs1040716:A, T + rs502958:A) associated with panic disorder in general regardless of the patient's gender (p < 0.05). These genotypes did not correlate with the patient's sex. Conclusions:We found two complex protective genotypes associated with panic disorder. This can be due to the fact that predisposition to the disease are associated with other genes, while PDE4B gene polymorphism reduces their effect.

SUBMITTER: Malakhova AV

PROVIDER: S-EPMC6803789 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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<i>PDE4B</i> gene polymorphism in Russian patients with panic disorder.

Malakhova Alena V AV Rudko Olga I OI Sobolev Vladimir V VV Tretiakov Artemii V AV Naumova Elena A EA Kokaeva Zarema G ZG Azimova Julia E JE Klimov Eugene A EA

AIMS genetics 20190820 3

<h4>Background</h4>Panic disorder is a complex disease of unclear etiology but with an apparent genetic component. <i>PDE4B</i> gene product is involved in many cell processes owing to its function-regulation of the level of a second messenger cAMP. <i>PDE4B</i> gene polymorphism has been shown to be associated with some mental disorders including panic disorder.<h4>Aims</h4>The goal of our study was to evaluate the role of 3 SNPs in the <i>PDE4B</i> gene in the development of panic disorder.<h4 ...[more]

PMID: 31663033

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Project description:BackgroundBrain-derived neurotrophic factor (BDNF) is a candidate for susceptibility locus of Panic disorder (PD). However, the findings about the role of the BDNF Val66Met variant in PD were not consistent. Till now, the relationship between BDNF Val66Met polymorphism and anxiety-related traits in PD patients has been rarely explored. This study aimed to explore the relationship among BDNF Val66Met polymorphism, plasma BDNF level and anxiety-related trait in Chinese PD patients.MethodThis multi-center study included 116 PD patients and 99 health controls. We detected single-nucleotide polymorphism (SNP) of BDNF rs6265 (Val66Met) and BDNF plasma level in the two groups. In addition, PD patients were administered the State-Trait Anxiety Inventory (STAI), Panic Disorder Severity Scale-Chinese Version (PDSS-CV) and Hamilton Anxiety Rating Scale (HAMA-14). Quantitative comparison of the differences of BDNF concentration among subjects with different genotypes and association between BDNF Val66Met genotype and trait anxiety were performed.ResultsThere were no significant differences in the genotype frequency (p = 0.79) or allele frequency (p = 0.88) between PD patients and health controls. BDNF plasma levels of PD patients were significantly lower than those in control group (p = 0.003). BDNF plasma levels of the Met/Met genotype were significantly lower than those of Val/Met genotype in PD patients (p = 0.033). PD patients carried Met/Met genotype showed significantly higher scores in STAI trait compared to those carried Val/Val genotype (p = 0.045) and Val/Met genotype (p = 0.018). STAI trait scores of PD patients with agoraphobia were significantly higher than those of patients without agoraphobia (p < 0.05). The ANCOVA showed that the dependent variable STAI trait score was significantly affected by factor "genotype" (Val/Val, Val/Met, Met/Met, p = 0.029), and covariate "agoraphobia" (p = 0.008). In this model, 11.5% of the variance of the STAI trait score was explained by the BDNF genotype. Contrast analysis showed STAI trait scores of Met/Met subjects were significantly higher than those of Val/Met (p = 0.018) and Val/Val individuals (p = 0.045).ConclusionWe found that anxiety trait was associated with the BDNF polymorphism in PD patients. BDNF Met/Met genotype may decrease plasma BDNF level and increase trait anxiety in panic disorder.

Dataset Information

PDE4B gene polymorphism in Russian patients with panic disorder.

Publications

<i>PDE4B</i> gene polymorphism in Russian patients with panic disorder.

Similar Datasets

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