Ontology highlight
ABSTRACT:
SUBMITTER: Oliveira LS
PROVIDER: S-EPMC6803841 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Oliveira Luciana S LS Estevão-Costa Maria Inácia MI Alvarenga Valéria G VG Vivas-Ruiz Dan E DE Yarleque Armando A Lima Augusto Martins AM Cavaco Ana A Eble Johannes A JA Sanchez Eladio F EF
Molecules (Basel, Switzerland) 20190926 19
Atroxlysin-III (Atr-III) was purified from the venom of <i>Bothrops atrox</i>. This 56-kDa protein bears N-linked glycoconjugates and is a P-III hemorrhagic metalloproteinase. Its cDNA-deduced amino acid sequence reveals a multidomain structure including a proprotein, a metalloproteinase, a disintegrin-like and a cysteine-rich domain. Its identity with bothropasin and jararhagin from <i>Bothrops jararaca</i> is 97% and 95%, respectively. Its enzymatic activity is metal ion-dependent. The divalen ...[more]