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Two New AChE Inhibitors Isolated from Li Folk Herb Heilaohu "Kadsura coccinea" Stems.


ABSTRACT: Two new triterpenoids, named kadsuricoccins A and B, together with three known ones, were isolated from the Li folk herb Heilaohu, the stems of Kadsura coccinea (Lem.) A. C. Smith, which was used for food and as a healthy supplement. Their structures were elucidated by comprehensive analyses of mass spectrometry (MS) and nuclear magnetic resonance (NMR) spectroscopic data. To search healthy components, an acetylcholinesterase (AChE) inhibitory activity test by Ellman's Method was conducted, kadsuricoccins A and B showed activity with the AChE inhibit index (AII) up to 68.96% ± 0.19% and 57.8% ± 0.11% at 94 nM (compared with positive control tacrine AII 79.80% ± 0.20%, 9.4 nM), respectively.

SUBMITTER: Huang SZ 

PROVIDER: S-EPMC6804138 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature

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Two New AChE Inhibitors Isolated from Li Folk Herb Heilaohu "<i>Kadsura coccinea</i>" Stems.

Huang Sheng Zhuo SZ   Duan Lin Ping LP   Wang Hao H   Mei Wen Li WL   Dai Hao Fu HF  

Molecules (Basel, Switzerland) 20191008 19


Two new triterpenoids, named kadsuricoccins A and B, together with three known ones, were isolated from the Li folk herb Heilaohu, the stems of <i>Kadsura coccinea</i> (Lem.) A. C. Smith, which was used for food and as a healthy supplement. Their structures were elucidated by comprehensive analyses of mass spectrometry (MS) and nuclear magnetic resonance (NMR) spectroscopic data. To search healthy components, an acetylcholinesterase (AChE) inhibitory activity test by Ellman's Method was conducte  ...[more]

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