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The Role of Adaptor Protein CARD9 in Colitis-Associated Cancer.

ABSTRACT: The adaptor protein CARD9 plays an important role in anti-fungal immunity responses, linking detection of fungi by surface receptors to activation of the transcription factor nuclear factor ?B (NF-?B). Recent studies indicate that CARD9 also plays different but vital roles during the development of colitis-associated colorectal cancer (CAC). This review summarizes the current understanding of CARD9 functions in CAC, and we discuss its potentially carcinogenic mechanisms.

SUBMITTER: Zhong X

PROVIDER: S-EPMC6804436 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature

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The Role of Adaptor Protein CARD9 in Colitis-Associated Cancer.

Zhong Xiaoming X Chen Bin B Liu Min M Yang Zhiwen Z

Molecular therapy oncolytics 20190830

The adaptor protein CARD9 plays an important role in anti-fungal immunity responses, linking detection of fungi by surface receptors to activation of the transcription factor nuclear factor κB (NF-κB). Recent studies indicate that CARD9 also plays different but vital roles during the development of colitis-associated colorectal cancer (CAC). This review summarizes the current understanding of CARD9 functions in CAC, and we discuss its potentially carcinogenic mechanisms. ...[more]

PMID: 31650020

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