Ontology highlight
ABSTRACT:
SUBMITTER: Wang S
PROVIDER: S-EPMC6804494 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Wang Shengzheng S Dong Guoqiang G Sheng Chunquan C
Acta pharmaceutica Sinica. B 20190606 5
The trend toward designing large hydrophobic molecules for lead optimization is often associated with poor drug-likeness and high attrition rates in drug discovery and development. Structural simplification is a powerful strategy for improving the efficiency and success rate of drug design by avoiding "molecular obesity". The structural simplification of large or complex lead compounds by truncating unnecessary groups can not only improve their synthetic accessibility but also improve their phar ...[more]