Ontology highlight
ABSTRACT:
SUBMITTER: Gan W
PROVIDER: S-EPMC6804628 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Gan Wei W Bragg Fiona F Walters Robin G RG Millwood Iona Y IY Lin Kuang K Chen Yiping Y Guo Yu Y Vaucher Julien J Bian Zheng Z Bennett Derrick D Lv Jun J Yu Canqing C Mahajan Anubha A Clarke Robert J RJ Li Liming L Holmes Michael V MV McCarthy Mark I MI Chen Zhengming Z
Diabetes 20190809 11
In observational studies, type 2 diabetes is associated with two- to fourfold higher risk of cardiovascular diseases (CVD). Using data from the China Kadoorie Biobank (CKB), we examined associations of genetically predicted type 2 diabetes with CVD among ∼160,000 participants to assess whether these relationships are causal. A type 2 diabetes genetic risk score (comprising 48 established risk variants) was associated with the presence of carotid plaque (odds ratio 1.17 [95% CI 1.05, 1.29] per 1 ...[more]