Ontology highlight
ABSTRACT:
SUBMITTER: Zhang M
PROVIDER: S-EPMC6804845 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Zhang Mengjun M Wang Shufeng S Guo Binbin B Meng Gang G Shu Chi C Mai Wenli W Zheng Qian Q Chen Xiaoling X Wu Yuzhang Y Wang Li L
Cellular & molecular immunology 20180628 6
Autoreactive CD8<sup>+</sup> T cells, which play an indispensable role in β cell destruction, represent an emerging target for the prevention of type 1 diabetes (T1D). Altered peptide ligands (APLs) can efficiently induce antigen-specific T cells anergy, apoptosis or shifts in the immune response. Here, we found that HLA-A*0201-restricted CD8<sup>+</sup> T cell responses against a primary β-cell autoantigen insulin epitope InsB1<sub>5-14</sub> were present in both NOD.β2m<sup>null</sup>.HHD NOD ...[more]