Inhibition of cyclooxygenase-2 activity in subchondral bone modifies a subtype of osteoarthritis.
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ABSTRACT:
SUBMITTER: Tu M
PROVIDER: S-EPMC6804921 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Publications
Inhibition of cyclooxygenase-2 activity in subchondral bone modifies a subtype of osteoarthritis.
Tu Manli M Yang Mi M Yu Nanxi N Zhen Gehua G Wan Mei M Liu Wenlong W Ji Baochao B Ma Hairong H Guo Qiaoyue Q Tong Peijian P Cao Li L Luo Xianghang X Cao Xu X
Bone research 20190911
Osteoarthritis (OA) causes the destruction of joints. Its pathogenesis is still under investigation, and there is no effective disease-modifying therapy. Here, we report that elevated cyclooxygenase-2 (COX-2) expression in the osteocytes of subchondral bone causes both spontaneous OA and rheumatoid arthritis (RA). The knockout of COX-2 in osteocytes or treatment with a COX-2 inhibitor effectively rescues the structure of subchondral bone and attenuates cartilage degeneration in spontaneous OA (S ...[more]
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