Ontology highlight
ABSTRACT:
SUBMITTER: Ashi MO
PROVIDER: S-EPMC6804933 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Ashi Mohamad Omar MO Srour Nivine N Lambert Jean-Marie JM Marchalot Anne A Martin Ophélie O Le Noir Sandrine S Pinaud Eric E Ayala Maria Victoria MV Sirac Christophe C Saulière Jérôme J Moreaux Jérôme J Cogné Michel M Delpy Laurent L
Cellular & molecular immunology 20180820 10
The error-prone V(D)J recombination process generates considerable amounts of nonproductive immunoglobulin (Ig) pre-mRNAs. We recently demonstrated that aberrant Ig chains lacking variable (V) domains can be produced after nonsense-associated altered splicing (NAS) events. Remarkably, the expression of these truncated Ig polypeptides heightens endoplasmic reticulum stress and shortens plasma cell (PC) lifespan. Many questions remain regarding the molecular mechanisms underlying this new truncate ...[more]