Ontology highlight
ABSTRACT:
SUBMITTER: Leinonen HM
PROVIDER: S-EPMC6804948 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Leinonen Hanna M HM Lipponen Eevi M EM Valkama Anniina J AJ Hynynen Heidi H Oruetxebarria Igor I Turkki Vesa V Olsson Venla V Kurkipuro Jere J Samaranayake Haritha H Määttä Ann-Marie AM Parker Nigel R NR Ylä-Herttuala Seppo S Lesch Hanna P HP
Molecular therapy. Methods & clinical development 20190829
The therapeutic efficacy of a lentiviral vector (LV) expressing the <i>herpes simplex virus</i> thymidine kinase (HSV-TK) was studied in an immunocompetent rat glioblastoma model. Intraperitoneal ganciclovir injections (50 mg/kg/day) were administered for 14 consecutive days, resulting in reduced tumor volumes as monitored by MRI. Survival analyses revealed a significant improvement among the LV-expressing HSV-TK (LV-TK)/ganciclovir-treated animals when compared to non-treated control rats. Howe ...[more]