Ontology highlight
ABSTRACT:
SUBMITTER: Teles RMB
PROVIDER: S-EPMC6805014 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Teles Rosane M B RMB Lu Jing J Tió-Coma Maria M Goulart Isabela M B IMB Banu Sayera S Hagge Deanna D Bobosha Kidist K Ottenhoff Tom H M THM Pellegrini Matteo M Geluk Annemieke A Modlin Robert L RL
PLoS neglected tropical diseases 20191010 10
Reversal reactions (RRs) in leprosy are characterized by a reduction in the number of bacilli in lesions associated with an increase in cell-mediated immunity against the intracellular bacterium Mycobacterium leprae, the causative pathogen of leprosy. To identify the mechanisms that contribute to cell-mediated immunity in leprosy, we measured changes in the whole blood-derived transcriptome of patients with leprosy before, during and after RR. We identified an 'RR signature' of 1017 genes that w ...[more]