Ontology highlight
ABSTRACT:
SUBMITTER: Lamas-Toranzo I
PROVIDER: S-EPMC6805156 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Lamas-Toranzo Ismael I Fonseca Balvís Noelia N Querejeta-Fernández Ana A Izquierdo-Rico María José MJ González-Brusi Leopoldo L Lorenzo Pedro L PL García-Rebollar Pilar P Avilés Manuel M Bermejo-Álvarez Pablo P
eLife 20191022
Zona pellucida (ZP), the extracellular matrix sheltering mammalian oocytes and embryos, is composed by 3 to 4 proteins. The roles of the three proteins present in mice have been elucidated by KO models, but the function of the fourth component (ZP4), present in all other eutherian mammals studied so far, has remained elusive. Herein, we report that <i>ZP4</i> ablation impairs fertility in female rabbits. Ovulation, fertilization and in vitro development to blastocyst were not affected by <i>ZP4< ...[more]