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Very early MRI responses to therapy as a predictor of later radiographic progression in early rheumatoid arthritis.


ABSTRACT: BACKGROUND:The objective of this study was to evaluate early changes in magnetic resonance imaging (MRI) and clinical disease activity measures as predictors of later structural progression in early rheumatoid arthritis (RA). METHODS:This was a post hoc analysis of data pooled across treatments from a three-arm (tofacitinib monotherapy, tofacitinib with methotrexate [MTX], or MTX monotherapy) trial of MTX-naïve patients with early, active RA. Synovitis, osteitis and erosions were assessed with the Outcome Measures in Rheumatology (OMERACT) RA MRI scoring system (RAMRIS) and RAMRIQ (automated quantitative RA MRI assessment system; automated RAMRIS) at months 0, 1, 3, 6 and 12. Radiographs were assessed at months 0, 6 and 12, and clinical endpoints were assessed at all timepoints. Univariate and multivariate analyses explored the predictive value of early changes in RAMRIS/RAMRIQ parameters and disease activity measures, with respect to subsequent radiographic progression. RESULTS:Data from 109 patients with a mean RA duration of 0.7?years were included. In univariate analyses, changes in RAMRIS erosions at months 1 and 3 significantly predicted radiographic progression at month 12 (both p?

SUBMITTER: Conaghan PG 

PROVIDER: S-EPMC6805378 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature

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Very early MRI responses to therapy as a predictor of later radiographic progression in early rheumatoid arthritis.

Conaghan Philip G PG   Østergaard Mikkel M   Troum Orrin O   Bowes Michael A MA   Guillard Gwenael G   Wilkinson Bethanie B   Xie Zhiyong Z   Andrews John J   Stein Amy A   Chapman Douglass D   Koenig Andrew A  

Arthritis research & therapy 20191021 1


<h4>Background</h4>The objective of this study was to evaluate early changes in magnetic resonance imaging (MRI) and clinical disease activity measures as predictors of later structural progression in early rheumatoid arthritis (RA).<h4>Methods</h4>This was a post hoc analysis of data pooled across treatments from a three-arm (tofacitinib monotherapy, tofacitinib with methotrexate [MTX], or MTX monotherapy) trial of MTX-naïve patients with early, active RA. Synovitis, osteitis and erosions were  ...[more]

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