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Serum folate levels in bipolar disorder: a systematic review and meta-analysis.


ABSTRACT: BACKGROUND:Bipolar disorder (BD) is a major psychiatric illness, however its physiopathology is unclear. The role of folate in the physiopathology of BD is controversial. We conducted this systematic review and meta-analysis to investigate the effect of folate in BD patients. METHODS:We performed a thorough literature study of the PubMed, Embase, ScienceDirect, ClinicalKey, Cochrane Library, ProQuest, Web of Science, and ClinicalTrials.gov databases until December 21st, 2018. Random effects meta-analysis was conducted. RESULTS:Six articles involving 481 patients with BD and 760 controls were included. The meta-analysis results suggested that serum folate levels in the patients with BD were significantly lower than those in the controls (Hedges' g?=?-?0.211, 95% confidence interval?=?-?0.391 to -?0.031, p =?0.021). CONCLUSION:The current meta-analysis show it might be association between lower serum folate levels and patient with BD. However, we could not distinguish the potentially confounding effects of mood states on the folate levels. Further prospective studies including subjects with different mood states and possible physiopathology are warranted to investigate the association between folate deficiency and the etiology of BD.

SUBMITTER: Hsieh YC 

PROVIDER: S-EPMC6805488 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature

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Serum folate levels in bipolar disorder: a systematic review and meta-analysis.

Hsieh Yung-Chi YC   Chou Li-Shiu LS   Lin Ching-Hua CH   Wu Hung-Chi HC   Li Dian-Jeng DJ   Tseng Ping-Tao PT  

BMC psychiatry 20191022 1


<h4>Background</h4>Bipolar disorder (BD) is a major psychiatric illness, however its physiopathology is unclear. The role of folate in the physiopathology of BD is controversial. We conducted this systematic review and meta-analysis to investigate the effect of folate in BD patients.<h4>Methods</h4>We performed a thorough literature study of the PubMed, Embase, ScienceDirect, ClinicalKey, Cochrane Library, ProQuest, Web of Science, and ClinicalTrials.gov databases until December 21st, 2018. Rand  ...[more]

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