Association of Circulating Ceramides With Cardiac Structure and Function in the Community: The Framingham Heart Study.

ABSTRACT: Background A higher circulating plasma ceramide ratio (C16:0/C24:0) is associated with an increased risk of heart failure, even after accounting for standard risk factors including lipid markers. However, the pathobiological mechanisms that underlie this association are incompletely understood. We tested the hypothesis that plasma ceramide ratio (C16:0/C24:0) is associated with adverse cardiac remodeling in the community. Methods and Results We evaluated 2652 Framingham Offspring Study participants (mean age, 66±9 years; 55% women) who attended their eighth examination cycle and underwent routine echocardiography and liquid chromatography-tandem mass spectrometry-based assays for circulating ceramide concentrations. We used multivariable linear regression models to relate C16:0/C24:0 (inde

SUBMITTER: Nwabuo CC 

PROVIDER: S-EPMC6806035 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature