Association Between Angiotensin-Converting Enzyme Inhibitors, Angiotensin Receptor Blockers, and Suicide.

ABSTRACT:

Importance

The renin-angiotensin system has been implicated in mood disorders. Angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) are among the most commonly used medications, yet their effects on mental health outcomes, particularly suicide, are poorly understood. This study examined the association between suicide and exposure to ACEIs and ARBs. Because of differences in their mode of action, it was speculated that ARBs would be associated with a higher risk of suicide than ACEIs.

Objective

To examine the association between suicide and exposure to ARBs compared with ACEIs.

Design, setting, and participants

This population-based nested case-control study of individuals aged 66 years and older used administrative claims database

SUBMITTER: Mamdani M 

PROVIDER: S-EPMC6806420 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature