The composition and functional protein subsystems of the human nasal microbiome in granulomatosis with polyangiitis: a pilot study.

ABSTRACT:

Background

Ear, nose and throat involvement in granulomatosis with polyangiitis (GPA) is frequently the initial disease manifestation. Previous investigations have observed a higher prevalence of Staphylococcus aureus in patients with GPA, and chronic nasal carriage has been linked with an increased risk of disease relapse. In this cross-sectional study, we investigated changes in the nasal microbiota including a detailed analysis of Staphylococcus spp. by shotgun metagenomics in patients with active and inactive granulomatosis with polyangiitis (GPA). Shotgun metagenomic sequence data were also used to identify protein-encoding genes within the SEED database, and the abundance of proteins then correlated with the presence of bacterial species on an annotated heatmap.

Results

SUBMITTER: Wagner J 

PROVIDER: S-EPMC6806544 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature