Ontology highlight
ABSTRACT:
SUBMITTER: Prill K
PROVIDER: S-EPMC6808450 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Prill Kendal K Carlisle Casey C Stannard Megan M Windsor Reid Pamela J PJ Pilgrim David B DB
PloS one 20191023 10
The structure and function of the sarcomere of striated muscle is well studied but the steps of sarcomere assembly and maintenance remain under-characterized. With the aid of chaperones and factors of the protein quality control system, muscle proteins can be folded and assembled into the contractile apparatus of the sarcomere. When sarcomere assembly is incomplete or the sarcomere becomes damaged, suites of chaperones and maintenance factors respond to repair the sarcomere. Here we show evidenc ...[more]