Ontology highlight
ABSTRACT:
SUBMITTER: Hahn MA
PROVIDER: S-EPMC6810389 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Hahn Maria A MA Jin Seung-Gi SG Li Arthur X AX Liu Jiancheng J Huang Zhijun Z Wu Xiwei X Kim Byung-Wook BW Johnson Jennifer J Bilbao Adrienne-Denise V AV Tao Shu S Yim Jacob A JA Fong Yuman Y Goebbels Sandra S Schwab Markus H MH Lu Qiang Q Pfeifer Gerd P GP
Science advances 20191023 10
The characteristics of DNA methylation changes that occur during neurogenesis in vivo remain unknown. We used whole-genome bisulfite sequencing to quantitate DNA cytosine modifications in differentiating neurons and their progenitors isolated from mouse brain at the peak of embryonic neurogenesis. Localized DNA hypomethylation was much more common than hypermethylation and often occurred at putative enhancers within genes that were upregulated in neurons and encoded proteins crucial for neuronal ...[more]