Ontology highlight
ABSTRACT:
SUBMITTER: Sherborne AL
PROVIDER: S-EPMC6810600 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Sherborne Amy L AL Davidson Philip R PR Yu Katharine K Nakamura Alice O AO Rashid Mamunur M Nakamura Jean L JL
Cell reports 20150903 11
Ionizing radiation (IR) is a mutagen that promotes tumorigenesis in multiple exposure contexts. One severe consequence of IR is the development of second malignant neoplasms (SMNs), a radiotherapy-associated complication in survivors of cancers, particularly pediatric cancers. SMN genomes are poorly characterized, and the influence of genetic background on genotoxin-induced mutations has not been examined. Using our mouse models of SMNs, we performed whole exome sequencing of neoplasms induced b ...[more]