In Vitro Activity of Rifampin, Rifabutin, Rifapentine, and Rifaximin against Planktonic and Biofilm States of Staphylococci Isolated from Periprosthetic Joint Infection.

ABSTRACT: The in vitro activities of rifampin, rifabutin, rifapentine, and rifaximin were tested against 200 periprosthetic joint infection (PJI)-associated staphylococci. Seven rifampin-resistant isolates had MICs of ?4??g/ml. Three isolates had rifampin MICs of 0.25 to 1 ?g/ml and harbored an Asp471Gly RpoB variant, suggesting that the CLSI rifampin-susceptible staphylococcal breakpoint of ?1 ?g/ml may be too high. The remaining isolates had rifampin MICs of ?0.016??g/ml, and the rifampin, rifabutin, rifapentine, and rifaximin minimum biofilm bactericidal concentrations (MBBC) for ?50% of isolates were 8, 1, 2, and 4 ?g/ml (for S. aureus) and 2, 0.06, 0.25, and 0.5 ?g/ml (for S. epidermidis), respectively, for rifampin-susceptible isolates. Nonrifampin rifamycins have promising staphylococcal activity, including antibiofilm activity.

SUBMITTER: Albano M 

PROVIDER: S-EPMC6811393 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature