Ontology highlight
ABSTRACT:
SUBMITTER: Poirel L
PROVIDER: S-EPMC6811418 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Poirel Laurent L Vuillemin Xavier X Kieffer Nicolas N Mueller Linda L Descombes Marie-Christine MC Nordmann Patrice P
Antimicrobial agents and chemotherapy 20191022 11
A plasmid-located fosfomycin resistance gene, <i>fosA8</i>, was identified from a CTX-M-15-producing <i>Escherichia coli</i> isolate recovered from urine. Identification of this gene was obtained by whole-genome sequencing. It encoded FosA8, which shares 79% and 78% amino acid identity with the most closely related FosA2 and FosA1 enzymes, respectively. The <i>fosA8</i> gene was located on a transferable 50-kb plasmid of IncN type encoding high-level resistance to fosfomycin. <i>In silico</i> an ...[more]