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Possible Binding of Piperine in Mycobacterium tuberculosis RNA Polymerase and Rifampin Synergism.

ABSTRACT: The activity of rifampin (RIF) and piperine was evaluated at the relative transcript levels of 12 efflux pumps (EPs), and an additional mechanism was proposed to be behind the synergic interactions of piperine plus RIF in Mycobacterium tuberculosis AutoDock v4.2.3 and Molegro v6 programs were used to evaluate PIP binding in M. tuberculosis RNA polymerase (RNAP). A hypothesis has been raised that piperine interferes in M. tuberculosis growth through RNAP inhibition, differently from what was previously endorsed for EP inhibition only.

SUBMITTER: Murase LS

PROVIDER: S-EPMC6811433 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature

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Possible Binding of Piperine in Mycobacterium tuberculosis RNA Polymerase and Rifampin Synergism.

Murase Letícia Sayuri LS Perez de Souza João Vítor JV Meneguello Jean Eduardo JE Seixas Flavio Augusto Vicente FAV Hegeto Laíse Adriane LA Scodro Regiane Bertin de Lima RBL Siqueira Vera Lucia Dias VLD Caleffi Ferracioli Katiany Rizzieri KR Cardoso Rosilene Fressatti RF

Antimicrobial agents and chemotherapy 20191022 11

The activity of rifampin (RIF) and piperine was evaluated at the relative transcript levels of 12 efflux pumps (EPs), and an additional mechanism was proposed to be behind the synergic interactions of piperine plus RIF in Mycobacterium tuberculosis AutoDock v4.2.3 and Molegro v6 programs were used to evaluate PIP binding in M. tuberculosis RNA polymerase (RNAP). A hypothesis has been raised that piperine interferes in M. tuberculosis growth through RNAP inhibition, different ...[more]

PMID: 31481438

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