Ontology highlight
ABSTRACT:
SUBMITTER: Zhou Y
PROVIDER: S-EPMC6811558 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Zhou Yifei Y Wang Xueqing X Song Mengjiao M He Zhidong Z Cui Guizhong G Peng Guangdun G Dieterich Christoph C Antebi Adam A Jing Naihe N Shen Yidong Y
Nature communications 20191023 1
Macroautophagy, a key player in protein quality control, is proposed to be systematically impaired in distinct tissues and causes coordinated disruption of protein homeostasis and ageing throughout the body. Although tissue-specific changes in autophagy and ageing have been extensively explored, the mechanism underlying the inter-tissue regulation of autophagy with ageing is poorly understood. Here, we show that a secreted microRNA, mir-83/miR-29, controls the age-related decrease in macroautoph ...[more]