Ontology highlight
ABSTRACT:
SUBMITTER: Welk V
PROVIDER: S-EPMC6811633 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Welk Vanessa V Meul Thomas T Lukas Christina C Kammerl Ilona E IE Mulay Shrikant R SR Schamberger Andrea C AC Semren Nora N Fernandez Isis E IE Anders Hans-Joachim HJ Günther Andreas A Behr Jürgen J Eickelberg Oliver O Korfei Martina M Meiners Silke S
Scientific reports 20191023 1
The proteasome is essential for the selective degradation of most cellular proteins and is fine-tuned according to cellular needs. Proteasome activators serve as building blocks to adjust protein turnover in cell growth and differentiation. Understanding the cellular function of proteasome activation in more detail offers a new strategy for therapeutic targeting of proteasomal protein breakdown in disease. The role of the proteasome activator PA200 in cell function and its regulation in disease ...[more]