Ontology highlight
ABSTRACT:
SUBMITTER: Bule P
PROVIDER: S-EPMC6811678 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Bule Pedro P Chuzel Léa L Blagova Elena E Wu Liang L Gray Melissa A MA Henrissat Bernard B Rapp Erdmann E Bertozzi Carolyn R CR Taron Christopher H CH Davies Gideon J GJ
Nature communications 20191023 1
Sialic acids are a family of related sugars that play essential roles in many biological events intimately linked to cellular recognition in both health and disease. Sialidases are therefore orchestrators of cellular biology and important therapeutic targets for viral infection. Here, we sought to define if uncharacterized sialidases would provide distinct paradigms in sialic acid biochemistry. We show that a recently discovered sialidase family, whose first member EnvSia156 was isolated from ho ...[more]