Ontology highlight
ABSTRACT:
SUBMITTER: Kotha S
PROVIDER: S-EPMC6811863 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
ACS omega 20191014 17
A new synthetic strategy to the ABCD ring system of the anticancer agent fredericamycin A (NSC-305263) was realized by the Diels-Alder reaction and olefin metathesis as key steps. The tactics developed here for the construction of the ABCD ring system also involve double Claisen rearrangement followed by a retro-Diels-Alder reaction and ring-closing metathesis. The metathesis approach performs a key role in the construction of A and D rings of the ABCD core unit. More importantly, ABCD fragment ...[more]