Data on the mechanobiological differences in the transcriptomes of human fetal and adult dermal fibroblasts in response to extracellular matrix rigidity.
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ABSTRACT:
SUBMITTER: Leih MJ
PROVIDER: S-EPMC6811905 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
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Data on the mechanobiological differences in the transcriptomes of human fetal and adult dermal fibroblasts in response to extracellular matrix rigidity.
Leih Mitchell J MJ Ramirez Marisol A MA Jerrell Rachel J RJ Parekh Aron A
Data in brief 20190918
Fetal skin is known to proceed through the wound healing process without the formation of scar tissue but rather via regeneration. Fetal dermal fibroblasts have emerged as a significant driving force in this regenerative response due to their unique phenotypic characteristics including our recent finding of an attenuated contractile response to extracellular matrix (ECM) rigidity that normally contributes to myofibroblast differentiation and scar formation. We provide data here that these mechan ...[more]
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2023-11-02 | GSE246562 | GEO