Ontology highlight
ABSTRACT:
SUBMITTER: Singhal S
PROVIDER: S-EPMC6812229 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Heliyon 20191011 10
Novel Schiff bases (SBs) were synthesized by condensation of 2-(1-Amino benzyl) benzimidazole with heterocyclic and aromatic carbonyl compounds. The structural characterization was done using <sup>1</sup>H, <sup>13</sup>C NMR, FTIR and ES-MS spectroscopic techniques. The <i>in silico</i> pharmacokinetics showed that nearly all compounds obeyed Lipinski rule of 5 with low toxicity and metabolic stability. The global reactivity descriptors were calculated using DFT approach. The molecular docking ...[more]