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Antimicrobial and wound healing properties of a bacterial cellulose based material containing B. subtilis cells.

ABSTRACT: A biocomposite composed of bacterial cellulose (BC) gel-film and Bacillus subtilis (BS) cells was obtained and characterized with a view to future biomedical applications. The inclusion of functional ingredient (1010/g viable BS cells) in the composite was carried out by their joint aggregation with the BC gel-film. Immobilized BS cells displayed high antagonistic activity towards causative agents of wound infections such as Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, Pseudomonas aeruginosa. Application of the BC/BS-biocomposite for the treatment of excision wounds, performed on laboratory animals, stimulated reparative processes and shortened the healing time. Possible mechanisms of the wound-healing effect of BC/BS gel films are discussed. In this work we claim that the developed BC/BS-material can be positioned as a universal wound coating and sanitary-hygienic product.

SUBMITTER: Savitskaya IS

PROVIDER: S-EPMC6812235 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature

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Antimicrobial and wound healing properties of a bacterial cellulose based material containing B. subtilis cells.

Savitskaya I S IS Shokatayeva D H DH Kistaubayeva A S AS Ignatova L V LV Digel I E IE

Heliyon 20191010 10

A biocomposite composed of bacterial cellulose (BC) gel-film and Bacillus subtilis (BS) cells was obtained and characterized with a view to future biomedical applications. The inclusion of functional ingredient (1010/g viable BS cells) in the composite was carried out by their joint aggregation with the BC gel-film. Immobilized BS cells displayed high antagonistic activity towards causative agents of wound infections such as Staphylococcus aureus, Staphylococcus epidermidis< ...[more]

PMID: 31667414

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