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Antimicrobial and wound healing properties of a bacterial cellulose based material containing B. subtilis cells.


ABSTRACT: A biocomposite composed of bacterial cellulose (BC) gel-film and Bacillus subtilis (BS) cells was obtained and characterized with a view to future biomedical applications. The inclusion of functional ingredient (1010/g viable BS cells) in the composite was carried out by their joint aggregation with the BC gel-film. Immobilized BS cells displayed high antagonistic activity towards causative agents of wound infections such as Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, Pseudomonas aeruginosa. Application of the BC/BS-biocomposite for the treatment of excision wounds, performed on laboratory animals, stimulated reparative processes and shortened the healing time. Possible mechanisms of the wound-healing effect of BC/BS gel films are discussed. In this work we claim that the developed BC/BS-material can be positioned as a universal wound coating and sanitary-hygienic product.

SUBMITTER: Savitskaya IS 

PROVIDER: S-EPMC6812235 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature

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Antimicrobial and wound healing properties of a bacterial cellulose based material containing <i>B. subtilis</i> cells.

Savitskaya I S IS   Shokatayeva D H DH   Kistaubayeva A S AS   Ignatova L V LV   Digel I E IE  

Heliyon 20191010 10


A biocomposite composed of bacterial cellulose (BC) gel-film and <i>Bacillus subtilis</i> (BS) cells was obtained and characterized with a view to future biomedical applications. The inclusion of functional ingredient (10<sup>10</sup>/g viable BS cells) in the composite was carried out by their joint aggregation with the BC gel-film. Immobilized BS cells displayed high antagonistic activity towards causative agents of wound infections such as <i>Staphylococcus aureus, Staphylococcus epidermidis<  ...[more]

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