Ontology highlight
ABSTRACT:
SUBMITTER: DeRossi C
PROVIDER: S-EPMC6812593 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
DeRossi Charles C Bambino Kathryn K Morrison Joshua J Sakarin Isabel I Villacorta-Martin Carlos C Zhang Changwen C Ellis Jillian L JL Fiel M Isabel MI Ybanez Maria M Lee Youngmin A YA Huang Kuan-Lin KL Yin Chunyue C Sakaguchi Takuya F TF Friedman Scott L SL Villanueva Augusto A Chu Jaime J
Hepatology (Baltimore, Md.) 20190524 6
The growing burden of liver fibrosis and lack of effective antifibrotic therapies highlight the need for identification of pathways and complementary model systems of hepatic fibrosis. A rare, monogenic disorder in which children with mutations in mannose phosphate isomerase (MPI) develop liver fibrosis led us to explore the function of MPI and mannose metabolism in liver development and adult liver diseases. Herein, analyses of transcriptomic data from three human liver cohorts demonstrate that ...[more]