Ontology highlight
ABSTRACT:
SUBMITTER: He C
PROVIDER: S-EPMC6812687 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
He Chunbo C Lv Xiangmin X Huang Cong C Angeletti Peter C PC Hua Guohua G Dong Jixin J Zhou Jin J Wang Zhengfeng Z Ma Bowen B Chen Xingcheng X Lambert Paul F PF Rueda Bo R BR Davis John S JS Wang Cheng C
Cell reports 20190301 10
HPV infections are common in healthy women and only rarely cause cervical cancer, suggesting that individual genetic susceptibility may play a critical role in the establishment of persistent HPV infection and the development of cervical cancer. Here, we provide convincing in vitro and in vivo evidence showing that differential expression and activation of YAP1 oncogene determine individual susceptibility to HPV infection and cervical carcinogenesis. We found that hyperactivation of YAP1 in mous ...[more]