Ontology highlight
ABSTRACT:
SUBMITTER: Fan Y
PROVIDER: S-EPMC6813132 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Fan Yue Y Vilgalys Tauras P TP Sun Shiquan S Peng Qinke Q Tung Jenny J Zhou Xiang X
Genome biology 20191024 1
Identifying genetic variants that are associated with methylation variation-an analysis commonly referred to as methylation quantitative trait locus (mQTL) mapping-is important for understanding the epigenetic mechanisms underlying genotype-trait associations. Here, we develop a statistical method, IMAGE, for mQTL mapping in sequencing-based methylation studies. IMAGE properly accounts for the count nature of bisulfite sequencing data and incorporates allele-specific methylation patterns from he ...[more]