Ontology highlight
ABSTRACT:
SUBMITTER: Bhagunde P
PROVIDER: S-EPMC6813166 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
CPT: pharmacometrics & systems pharmacology 20191004 10
Relebactam is a small-molecule β-lactamase inhibitor developed as a fixed-dose combination with imipenem/cilastatin. The pharmacokinetics of relebactam and imipenem across 10 clinical studies were analyzed using data from adult healthy volunteers and patients with bacterial infections. Renal function estimated by creatinine clearance significantly affected the clearance of both compounds, whereas weight and health status were of less clinical significance. Simulations were used to calculate prob ...[more]