Ontology highlight
ABSTRACT:
SUBMITTER: Cheng CF
PROVIDER: S-EPMC6813364 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Cheng Ching-Feng CF Ku Hui-Chen HC Cheng Jing-Jy JJ Chao Shi-Wei SW Li Hsiao-Fen HF Lai Pei-Fang PF Chang Che-Chang CC Don Ming-Jaw MJ Chen Hsi-Hsien HH Lin Heng H
Communications biology 20191024
Billions of people have obesity-related metabolic syndromes such as diabetes and hyperlipidemia. Promoting the browning of white adipose tissue has been suggested as a potential strategy, but a drug still needs to be identified. Here, genetic deletion of activating transcription factor 3 (<i>ATF3</i><sup><i>-/-</i></sup> ) in mice under a high-fat diet (HFD) resulted in obesity and insulin resistance, which was abrogated by virus-mediated ATF3 restoration. ST32da, a synthetic ATF3 inducer isolat ...[more]