Apolipoprotein E Genotypes, Age, Race, and Cognitive Decline in a Population Sample.
Ontology highlight
ABSTRACT: OBJECTIVES:To examine the effects of age and race on the association of apolipoprotein E (APOE) genotypes with cognitive decline in a population sample. DESIGN:Longitudinal study of 18 years' duration. SETTING:Biracial urban US population sample. PARTICIPANTS:There were a total of 5807 participants, 60% African American (AA) and 40% European American (EA). MEASUREMENTS:A composite cognitive function based on individual tests of episodic memory, perceptual speed, and the Mini-Mental State Examination. RESULTS:The frequencies of APOE ?2/?3 (14% vs 12%), ?2/?4 (4% vs 2%), ?3/?4 (29% vs 22%), and ?4/?4 (4% vs 2%) genotypes were higher among AAs than EAs. After adjusting for demographic factors, the rate of decline in global cognition was twice as high among participants with the APOE ?4/?4 genotype compared to participants with the APOE ?3/?3 genotype (0.097 vs 0.048 SD units [SDUs] per year; P < .0001). This doubling was not different between AAs (0.091 vs 0.045 SDUs per year) and EAs (0.118 vs 0.059 SDUs per year) (Pinteraction = .63). The APOE ?3/?4 genotype was associated with a higher rate of decline with age (Pinteraction = .021), while the APOE ?2/?4 genotype (Pinteraction = .016) and the APOE ?2/?3 genotype (Pinteraction = .043) were associated with a lower rate of decline with higher age. The APOE ?2/?2 genotype was associated with a lower rate of decline in episodic memory, while the APOE ?2/?4 was associated with a higher rate of decline in episodic memory and perceptual speed. CONCLUSIONS:The association of the APOE genotypes with cognitive decline was not different between AAs and EAs. However, individuals with different APOE genotypes showed a lower or a higher rate of decline with age. J Am Geriatr Soc 67:734-740, 2019.
SUBMITTER: Rajan KB
PROVIDER: S-EPMC6813761 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
ACCESS DATA