Ontology highlight
ABSTRACT:
SUBMITTER: Okada BK
PROVIDER: S-EPMC6814388 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Okada Bethany K BK Li Anran A Seyedsayamdost Mohammad R MR
Chembiochem : a European journal of chemical biology 20190703 15
An alternative solution to the cyclical development of new antibiotics is the concept of disarming pathogens without affecting their growth, thereby eliminating the selective pressures that lead to resistant phenotypes. Here, we have employed our previously developed HiTES methodology to identify one such compound against the ESKAPE pathogen Pseudomonas aeruginosa. Rather than induce silent biosynthetic gene clusters, we used HiTES to suppress actively expressed virulence genes. By screening a l ...[more]