Ontology highlight
ABSTRACT:
SUBMITTER: Rajkumar-Calkins AS
PROVIDER: S-EPMC6815104 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Rajkumar-Calkins Anne S AS Szalat Raphael R Dreze Matija M Khan Iman I Frazier Zoë Z Reznichenkov Elizaveta E Schnorenberg Mathew R MR Tsai Yi-Fang YF Nguyen Huy H Kochupurakkal Bose B D'Andrea Alan D AD Shapiro Geoffrey I GI Lazaro Jean-Bernard JB Mouw Kent W KW
DNA repair 20190830
Homologous recombination deficiency conferred by alterations in BRCA1 or BRCA2 are common in breast tumors and can drive sensitivity to platinum chemotherapy and PARP inhibitors. Alterations in nucleotide excision repair (NER) activity can also impact sensitivity to DNA damaging agents, but NER activity in breast cancer has been poorly characterized. Here, we apply a novel immunofluorescence-based cellular NER assay to screen a large panel of breast epithelial and cancer cell lines. Although the ...[more]