Ontology highlight
ABSTRACT:
SUBMITTER: Irene C
PROVIDER: S-EPMC6815149 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Irene Carmela C Fantappiè Laura L Caproni Elena E Zerbini Francesca F Anesi Andrea A Tomasi Michele M Zanella Ilaria I Stupia Simone S Prete Stefano S Valensin Silvia S König Enrico E Frattini Luca L Gagliardi Assunta A Isaac Samine J SJ Grandi Alberto A Guella Graziano G Grandi Guido G
Proceedings of the National Academy of Sciences of the United States of America 20191007 43
Bacterial outer membrane vesicles (OMVs) represent an interesting vaccine platform for their built-in adjuvanticity and simplicity of production process. Moreover, OMVs can be decorated with foreign antigens using different synthetic biology approaches. However, the optimal OMV engineering strategy, which should guarantee the OMV compartmentalization of most heterologous antigens in quantities high enough to elicit protective immune responses, remains to be validated. In this work we exploited t ...[more]