Ontology highlight
ABSTRACT:
SUBMITTER: Tseng WY
PROVIDER: S-EPMC6815167 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Tseng Wen-Yi WY Huang Yi-Shu YS Clanchy Felix F McNamee Kay K Perocheau Dany D Ogbechi Joy J Luo Shue-Fen SF Feldmann Marc M McCann Fiona E FE Williams Richard O RO
Proceedings of the National Academy of Sciences of the United States of America 20191009 43
Regulatory T (Treg) cells expressing the transcription factor Foxp3 play an important role in maintaining immune homeostasis. Chronic inflammation is associated with reduced Foxp3 expression, function, and loss of phenotypic stability. Previous studies have established the importance of TNF receptor 2 (TNFR2) in the generation and/or activation of Treg cells. In this study, we assess the importance of TNFR2 in healthy mice and under inflammatory conditions. Our findings reveal that, in health, T ...[more]